Healthcare sector represents a large share of the global economy (about 10% of global economic output) and employs a large number of workers, thus it is imperative to be efficient, effective, resilient and sustainable in the face of significant challenges, risks and at the same time provide sustainable development goals and digital transformation to healthcare users, through limited governmental resources. The current global financial crisis, the COVID19 pandemic, the growing socio-economic inequalities and negative consequences of greenhouse gas emissions causing the climate change, have become issues of growing concern. Organizations worldwide responded to these new challenges of sustainable finance integrating environmental, social, and corporate governance (ESG) factors and the digital transformation into their innovation business strategies. In this paper, we investigate the role, importance and correlation of ESG factors and the Digital Transformation for the Sustainable Finance of Healthcare Systems and a set of proposed actions and strategies are presented, for the sustainability and resilience of the Healthcare Sector.