Many researchers have studied the factors that impact on students’ entrepreneurial intention; however, findings are conflicting. The present study attempts, through an extensive review of the literature, to provide a holistic view and deeper knowledge of the most significant factors that influence university students’ decisions to be self-employed or to start a business. A systematic review as well as a bibliometric analysis of the literature was implemented, using a three-step literature mapping protocol to search, select, evaluate, and validate the literature by examining and analyzing numerous papers from the scientific community. The process ended up with 677 papers, from which the forty-three most cited were used as our research sample. Findings revealed that there are four primary categories of factors: the contextual factors, such as the economic, social, and political environment, the motivational factors, such as individuals’ personal needs, personality traits, and characteristics, and the factors related with the personal background of individuals such as family, education, and peers. We also examined the countries with the maximum number of papers on university students’ entrepreneurial intentions. These findings can be useful for policy makers and educators and will serve as a basis for future research, while they also contribute to the literature by highlighting the factors that most affect the entrepreneurial intention of university students.