DC FieldValueLanguage
dc.contributor.authorBournia, Vasiliki-Kalliopi-
dc.contributor.authorFragoulis, George E.-
dc.contributor.authorMitrou, Panagiota-
dc.contributor.authorMathioudakis, Konstantinos-
dc.contributor.authorKonstantonis, George-
dc.contributor.authorTektonidou, Maria G.-
dc.contributor.authorTsolakidis, Anastasios-
dc.contributor.authorParaskevis, Dimitrios-
dc.contributor.authorSfikakis, Petros P.-
dc.date.accessioned2025-03-07T13:49:38Z-
dc.date.available2025-03-07T13:49:38Z-
dc.date.issued2024-04-01-
dc.identifierscopus-85189512480-
dc.identifier.issn1462-0332-
dc.identifier.issn1462-0324-
dc.identifier.other85189512480-
dc.identifier.urihttps://uniwacris.uniwa.gr/handle/3000/3005-
dc.description.abstractObjectives: Patients with RA were at increased risk for COVID-19-associated hospitalization and death during the first year of the pandemic in Greece. We aimed to examine their outcomes after the SARS-Cov-2 Omicron, a more contagious but with milder clinical impacts variant, prevailed. Methods: A retrospective, nationwide study was conducted between 1 January 2022 and 30 June 2022 in all RA patients under treatment and matched (1:5) on age, sex and region of domicile random general population comparators. Confirmed SARS-CoV-2 infections, hospitalizations and deaths, anti-rheumatic medications, prior COVID-19, vaccinations and anti-viral medications were recorded. Results: Among 34 182 RA patients, infections (n ¼ 5569, 16.29%), hospitalizations (n ¼ 489, 1.43%) and deaths (n ¼ 106, 0.31%) were more frequent than among comparators. Incidence rates per 1000 person/years of infection [IRR (95% CI):1.19 (1.16, 1.23)], hospitalization [IRR (95% CI):2.0 (1.82, 2.24)], and death [IRR (95% CI):1.81 (1.44, 2.27)] were increased in RA despite better vaccination coverage (89% vs 84%) and more frequent use of anti-viral medications (2.37% vs 1.08). Logistic regression analysis after correcting for age, sex, vaccinations, prior COVID-19, and anti-viral medications in SARS-CoV-2 infected RA patients and comparators revealed increased risk of hospitalization (OR: 2.02, 95% CI: 1.79, 2.27) and death [OR: 1.73, (95% CI: 1.36, 2.20)] in RA. Among infected RA patients, rituximab treatment conferred increased risks for hospitalization [OR: 6.12, (95% CI: 2.89, 12.92)] and death [OR: 12.06 (95% CI: 3.90, 37.31)], while JAK inhibitors increased only hospitalization risk [OR: 2.18 (95% CI: 1.56, 3.06)]. Conclusion: RA remains a risk factor for hospitalization and death in an era of a relatively low COVID-19 fatality rate, pointing to the need of perseverance in vaccination programs and wider use of anti-viral medications.en_US
dc.language.isoenen_US
dc.relation.ispartofRheumatologyen_US
dc.subjectCOVID-19en_US
dc.subjectΜortalityen_US
dc.subjectRAen_US
dc.titleOutcomes of COVID-19 Omicron variant in patients with rheumatoid arthritis: a nationwide Greek cohort studyen_US
dc.typeArticleen_US
dc.identifier.doi10.1093/rheumatology/kead354en_US
dc.identifier.scopus2-s2.0-85189512480-
dcterms.accessRights1en_US
dc.relation.deptDepartment of Archival, Library and Information Studiesen_US
dc.relation.facultySchool of Administrative, Economics and Social Sciencesen_US
dc.relation.volume63en_US
dc.relation.issue4en_US
dc.identifier.spage1130en_US
dc.identifier.epage1138en_US
dc.collaborationUniversity of West Attica (UNIWA)en_US
dc.subject.fieldSocial Sciencesen_US
dc.journalsOpen Accessen_US
dc.publicationPeer Revieweden_US
dc.countryGreeceen_US
local.metadatastatusverifieden_US
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.languageiso639-1en-
item.grantfulltextnone-
crisitem.author.deptDepartment of Archival, Library and Information Studies-
crisitem.author.facultySchool of Administrative, Economics and Social Sciences-
crisitem.author.orcid0000-0001-7364-4542-
crisitem.author.parentorgSchool of Administrative, Economics and Social Sciences-
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