This paper will negotiate on a basic scientific question and will examine how Social Enterprises can be strengthened through companies, which apply Corporate Social Responsibility (CSR) and how European Union policy strategies regarding Sustainable Development will promote this mutual and beneficial cooperation. The findings of this scientific question will provide discussion topics on the scope-how companies, which apply CSR can be used by social enterprises and vice versa, in order to create economic and social value for the companies and the local communities. In the era of financial crisis, our research suggests new strategies and innovation practices that will define the cooperation, between companies, which apply CSR and Social Enterprises (SE) in order to create synergy in the EU and Greek Sustainable Development Policies.