This chapter explains what organizational culture is and analyzes its importance for the management of any company. Organizational culture must not be ignored during the decision-making process and managers must understand the existing culture of their organization in order to achieve their targets and to meet their goals. This chapter presents the theoretical link between organizational culture and a variety of variables, which affect organizational performance and efficiency, directly and indirectly. Such variables are knowledge management, organizational climate, leadership, quality, innovation and entrepreneurship, human resource management, and employee behavior. This chapter creates the starting point to study the link between culture and organizational strategy, enterprising practices and change management.