Greece due to its geographical location received 51,110 asylum applications in 2016. Given the country’s universal coverage by a public system, all Greek population and refugees have access to health care. The aim of this study was to compare the quality of life between Greek and refugees’ postpartum mothers in a public obstetric hospital. This is a cross-sectional study. The study participants were 110 postpartum women referred to largest public obstetric hospital. Specifically, 55 Greek postpartum mothers and 55 refugees were randomly selected. Data collection tools was the SF-36 questionnaire. The SF-36 was translated in English and Arabic languages. The duration of the study was November 2017–January 2018. Data were analyzed using SPSS 25. The majority of refugees’ sample (78.2%) belonged to 25–34 years as well as 61.8% of Greek sample. The mean of physical component was 47.7 for refugees and 48.4 for Greek women, mental component was 22.8 and 41.6 respectively. All dimensions of SF-36 were found statistically significant between two groups (p ≤ 0.001), except from BP. Moreover, the satisfaction of hospital obstetric services was correlated with dimension VT (r = −0.291) and SF (r = 0.296) in the group of refugees’ postpartum mothers. However, no correlation was found in the corresponding group of Greek women. Policy makers need to prioritize aspects of psychological problems among refugees. Also, health professionals have a crucial role to play through their expertise in advocacy for improvements in policy and service development.