The research examines whether the changes that have taken place in the global business environment have modulated the way firms do business or whether it is simply transient details that have caused such excitement. Should firms be wary of any proclamations of 'new' ways of doing business? Or should they ignore changes of the business environment? Semi-structured in-depth interviews were conducted in three focus groups of managers from three major firms operating in Greece. The influence of globalization, the intense competition and new technologies in B2B e-commerce are external factors that raise problems and complexities in the future direction of Greek firms. There is also a gap caused by the lack of an innovation culture between top and lesser management. Businesses are required to modernise their practices to move from their present situation at the level of the 2nd industrial revolution of "old economy" to the 3rd industrial revolution of "new era economy". The results of this research can be used to assist companies to move to e- business taking into consideration account the external and internal factors with regard to the ways in which e-relationships can be modulated.