This paper aims to examine the direct effect of the HEXACO personality traits on entrepreneurial intention and career adaptability, the indirect effect of personality traits on entrepreneurial intention through career adaptability, and the direct effect of career adaptability on entrepreneurial intention. A 55-item questionnaire was employed to measure the personality traits of HEXACO, career adaptability, and entrepreneurial intention. The study sample includes more than half of the students of the business department (n = 485) of a public university based in Athens. The results indicate that extraversion, conscientiousness, and openness have a direct and positive impact on entrepreneurial intention, while emotionality has a negative one. Also, career adaptability relates positively to entrepreneurial intention. Openness, conscientiousness, extraversion, and humility affect positively career adaptability. Finally, it is indicated that openness, conscientiousness, extraversion, and humility have an indirect and positive relationship with entrepreneurial intention through career adaptability. The data were empirically tested using the Jamovi program that uses the R code for designing the analysis (Rosseel, 2019). These findings suggest the need for more studies that will investigate the validity of the findings presented here in different settings (McKenna, Zacher, Ardabili, & Mohebbi, 2016; Brännback & Carsrud, 2018).