The deployment of a simple-link sensor network-based physiological signal remote monitoring system is presented in this chapter. The proposed system consists of a Wireless Portable Sensor Unit (WPSU), which is installed at the patient’s home and measures the physiological signals and sends these to the remote monitoring station (i.e., at a hospital) through a wireless access point unit (home router). The received data of every patient is stored in the database server for review. Significant experiments have been carried out to evaluate the current consumption, life expectancy, and movement of a patient in an environment. From the experiments, it is observed that the current consumption and life expectancy of a WPSU has been found as 0.01529 A and two days 17 hours 24 minutes, respectively. Also, it is evaluated that the maximum mobility of a WPSU in an environment is 119-m line of sight from the wireless access point.