Natural History Museums (NHMs) are unique spaces that have only recently come to comprehend the effectiveness of the learning opportunities they offer to their visitors. Their collections form a rich source of knowledge about Earth’s biodiversity and natural history with a high quality scientific content aiming with the exploitation of new online technologies and tools to become available to everyone. In this paper, we focus in the use of digital cultural resources, and more specifically digital natural history and biodiversity content, for the development of educational activities in the context of Natural History Museums and Science Centers. Moreover the proposed approach aims to enhance the learning process that takes place in the formal environment of the classroom, in fulfilling ways that cannot be compared to school learning, while also building on the National Curriculum. The Natural Europe project goal is to study and adopt educational methods recognized by European Union and to implement them deploying innovative learning design tools.